Publications

Le Dr Carolyn Jack est dermatologue et immunologiste formée au doctorat. Elle possède une expertise en biologie moléculaire, en immunologie cellulaire, en immunophénotypage de cellules et de tissus humains primaires, en modélisation préclinique de maladies humaines in vitro et en essais cliniques basés sur des biospécimens de peau. Elle occupe les postes de professeure adjointe à l'Université McGill, de scientifique junior au programme Maladies infectieuses et immunité en santé mondiale de l'Institut de recherche du Centre universitaire de santé McGill (IR-CUSM).

Son travail clinique et ses recherches sont axés sur la dermatite atopique (DA) de l'adulte, dans le but d'identifier des interventions modificatrices de la maladie dans la DA chronique. Pour une liste complète des travaux publiés par le Dr. Jack, veuillez visiter :

https://www.ncbi.nlm.nih.gov/myncbi/1dwy2dlQsgIM1O/bibliography/public/

Publications :

Ratnarajah K, Le M, Muntyanu A, Mathieu S, Nigen S, Litvinov IV, Jack CS, Netchiporouk E. Inhibition of IL-13: A New Pathway for Atopic Dermatitis [Formula: see text]. J Cutan Med Surg. 2021 May-Jun;25(3):315-328. doi: 10.1177/1203475420982553. Epub 2020 Dec 22. Review. PubMed PMID: 33350863.

Maintz L, Bieber T, Bissonnette R, Jack C. Measuring Atopic Dermatitis Disease Severity: The Potential for Electronic Tools to Benefit Clinical Care. J Allergy Clin Immunol Pract. 2021 Apr;9(4):1473-1486.e2. doi: 10.1016/j.jaip.2021.02.027. PubMed PMID: 33838840.

He H, Bissonnette R, Wu J, Diaz A, Saint-Cyr Proulx E, Maari C, Jack C, Louis M, Estrada Y, Krueger JG, Zhang N, Pavel AB, Guttman-Yassky E. Tape strips detect distinct immune and barrier profiles in atopic dermatitis and psoriasis. J Allergy Clin Immunol. 2021 Jan;147(1):199-212. doi: 10.1016/j.jaci.2020.05.048. Epub 2020 Jul 21. PubMed PMID: 32709423.

Papp, K. A., Hong, C-H, Lansang, M. P., Turchin, I., Adam, D. N., Beecker, J. R., Bissonnette, R., Gooderham, M. J., Jack, C., Joseph, M., Lynde, C. W., Shear, N. H. 2021. Practical Management of Patients with Atopic Dermatitis on Dupilumab. Dermatology & Therapy. https://doi.org/10.1007/s13555-021-00586-w.

Belmesk, L., Muntyanu, A., Cantin, E., AlHalees, Z., Jack, C., Le, M., Sasseville, D., Iannattone, L., Ben-Shoshan, M., Litvinov, I.V., Netchiporouk, E. 2021. Prominent Role of Type 2 Immunity in Skin Diseases-Beyond Atopic Dermatitis. J Cutan Med Surg. doi:10.1177/12034754211027858.

Del Duca E, Pavel AB, Dubin C, Song T, Wallace EB, Peng X, Estrada YD, Xu H, Maari C, Jack C, St-Cyr Proulx E, Krueger JG, Bissonnette R, Guttman-Yassky E. Major Differences in Expression of Inflammatory Pathways in Skin from Different Body Sites of Healthy Individuals. J Invest Dermatol. 2019 Oct;139(10):2228-2232.e10. doi: 10.1016/j.jid.2019.04.008. Epub 2019 May 3. PubMed PMID: 31059695.

Jack C, Mashiko S, Arbour N, Bissonnette R, Sarfati M. Persistence of interleukin (IL)-17A+ T lymphocytes and IL-17A expression in treatment-resistant psoriatic plaques despite ustekinumab therapy. Br J Dermatol. 2017 Jul;177(1):267-270. doi: 10.1111/bjd.15029. Epub 2017 Jun 6. PubMed PMID: 27599204.

Jack C, El Helou T. Non-healing ulcerative paronychia. Lancet. 2017 Apr 29; 389(10080):1740. doi: 10.1016/S0140-6736(16)32400-X. Epub 2016 Dec 23. PubMed PMID: 28017401.

Jack C, Hazel E, Bernatsky S. Something's missing here: a look at the quality of rheumatology referral letters. Rheumatol Int. 2012 Apr;32(4):1083-5. doi: 10.1007/s00296-011-1832-z. Epub 2011 Feb 22. PubMed PMID: 21340567.

Jack CS, Arbour N, Blain M, Meier UC, Prat A, Antel JP. Th1 polarization of CD4+ T cells by Toll-like receptor 3-activated human microglia. J Neuropathol Exp Neurol. 2007 Sep;66(9):848-59. doi: 10.1097/nen.0b013e3181492a7. PubMed PMID: 17805015.

Jack C, Antel J, Brück W, Kuhlmann T. Contrasting potential of nitric oxide and peroxynitrite to mediate oligodendrocyte injury in multiple sclerosis. Glia. 2007 Jul;55(9):926-34. doi: 10.1002/glia.20514. PubMed PMID: 17437305.

Shapiro AM, Jack CS, Lapierre Y, Arbour N, Bar-Or A, Antel JP. Potential for interferon beta-induced serum antibodies in multiple sclerosis to inhibit endogenous interferon-regulated chemokine/cytokine responses within the central nervous system. Arch Neurol. 2006 Sep; 63(9):1296-9. doi: 10.1001/archneur.63.9.1296. PubMed PMID: 16966508.

Wiendl H, Feger U, Mittelbronn M, Jack C, Schreiner B, Stadelmann C, Antel J, Brueck W, Meyermann R, Bar-Or A, Kieseier BC, Weller M. Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity. Brain. 2005 Nov;128(Pt 11):2689-704. doi: 10.1093/brain/awh609. Epub 2005 Aug 25. PubMed PMID: 16123145.

Jack CS, Arbour N, Manusow J, Montgrain V, Blain M, McCrea E, Shapiro A, Antel JP. TLR signaling tailors innate immune responses in human microglia and astrocytes. J Immunol. 2005 Oct 1;175(7):4320-30. doi: 10.4049/jimmunol.175.7.4320. PubMed PMID: 16177072.

Jack C, Ruffini F, Bar-Or A, Antel JP. Microglia and multiple sclerosis. J Neurosci Res. 2005 Aug 1;81(3):363-73. doi: 10.1002/jnr.20482. Review. PubMed PMID: 15948188.

Magnus T, Schreiner B, Korn T, Jack C, Guo H, Antel J, Ifergan I, Chen L, Bischof F, Bar-Or A, Wiendl H. Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS. J Neurosci. 2005 Mar 9;25(10):2537-46. doi: 10.1523/JNEUROSCI.4794-04.2005. PubMed PMID: 15758163; PubMed Central PMCID: PMC6725171.